hypoxia tolerance - meaning and definition. What is hypoxia tolerance
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What (who) is hypoxia tolerance - definition

FAMILY OF PROTEIN COMPLEXES
Hypoxia inducible factor; Hypoxia Inducible Factors; Hypoxia-inducible factor 1; Hypoxia inducible factor 1a; Hypoxia Inducible Factor; HIF-1; Hypoxia-inducible factors; Hypoxia inducible factors; Hypoxia signaling; Hypoxia-inducible factor-1; Hif1
  • Nobel Prize in Physiology or Medicine 2019: How Cells Sense and Adapt to Oxygen Availability. Under normoxic conditions, Hif-1 alpha is hydroxylated at two proline residues. It then associates with VHL and is tagged with ubiquitin resulting in proteasomal degradation. Under hypoxic conditions, Hif-1 alpha translocates to the cell nucleus and associates with Hif-1 beta. This complex then binds to the HRE region of the DNA resulting in the transcription of genes that are involved in a multitude of processes including erythropoesis, glycolysis, and angiogenesis.

Silent hypoxia         
FORM OF HYPOXIA THAT DOES NOT COINCIDE WITH SHORTNESS OF BREATH
Draft:Silent hypoxia; Happy hypoxia
Silent hypoxia (also happy hypoxia) is hypoxia that does not coincide with shortness of breath. It is known to be a complication of COVID-19.
Drug tolerance         
PHARMACOLOGICAL CONCEPT DESCRIBING SUBJECTS' REDUCED REACTION TO A DRUG FOLLOWING ITS REPEATED USE
Physiological tolerance; Tolerance (pharmacology)
Drug tolerance or drug insensitivity is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use. Increasing its dosage may re-amplify the drug's effects; however, this may accelerate tolerance, further reducing the drug's effects.
Hypoxia-inducible factor         
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia.

Wikipedia

Hypoxia-inducible factor

Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. They are only present in parahoxozoan animals.